Forecasters have posted a blizzard warning for the eastern Dakotas and western Minnesota as snow, strong winds and plunging temperatures move in.
The storm is creating difficult travel conditions early Wednesday with a large number of schools canceling classes, including North Dakota State University and Minnesota State University Moorhead.
The North Dakota Department of Transportation said Interstate 29 is closed in both directions from the Canadian border to the state line of South Dakota.
Meteorologists expected wind gusts to 50 mph and whiteout conditions, especially in open, rural areas.
Snow accumulations will be low, at 1 to 2 inches expected.